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Inquire Now About Our 20+ Years Discovery DMPK & ADME Services At FDA Audited Bioanalytical Lab

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    • Cross-Species Microsomal, Hepatocyte, Plasma Stability For Diverse Modalities
    • Regulatory-Grade DDI With 7-Isoform CYP Inhibition, CYP Induction, PPB, Transporter Panels
    • Caco-2, MDCK-MDR1, PAMPA Permeability With Efflux Ratios To Flag P-gp Substrates
    • PhD-Led Met ID Or Soft-Spot Analysis On HRMS And HPLC-MS/MS With ~2-3 Week Turnaround

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Good Laboratory Practice for Nonclinical Laboratory Studies | NorthEast BioLab Food and Drug Administration (FDA | NorthEast BioLab College Of American Pathologists | NorthEast BioLab International Orgaization for Standardization | NorthEast BioLab
+ Years Of Bioanalysis
+ Small/Large Molecule Studies
+ Custom Bioanalytical Assays
+ Investigational Drugs
+ Biomarker & Cytokine Assays

From Discovery Through IND - In Vitro ADME, DMPK & Met ID Services For Small Molecules, Biologics, Peptides

Microsomal Stability

Microsomal Stability

Test compound depletion measured by LC-MS/MS for intrinsic clearance and half-life

Hepatocyte Stability

Hepatocyte Stability

Cross-species hepatocyte incubations for intrinsic clearance, t½, metabolic soft spots

CYP Induction Assay

CYP Induction Assay

Cryopreserved human hepatocytes with mRNA fold-change and EC50 reporting across AhR, CAR, PXR

CYP Inhibition Assay

CYP Inhibition Assay

7-isoform IC50 panel and time-dependent IC50 shift in pooled human liver microsomes for DDI risk

Metabolite Identification

Metabolite Identification

Identification and characterization of drug metabolites using high-resolution mass spectrometry

Plasma Protein Binding

Plasma Protein Binding

Fraction unbound across species using rapid equilibrium dialysis

Permeability Assays

Permeability Assays

Apparent permeability and efflux ratios to flag P-gp substrates

Transporter Assays

Transporter Assays

DDI risk via MDR1, BCRP, OATP1B1/1B3, OAT1/3, OCT2, MATE1/2-K, BSEP substrate/inhibition

Don’t Wait, Start Your Drug Metabolism and Pharmacokinetics (ADME) Today!

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100+ Biotechs. 500+ Custom Assays. One Agile, FDA-Inspected ADME Services CRO.

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Executive Director, Pharmacokinetics

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