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How to use Ultra-Low Temperature (ULT) Freezers in Drug R&D Laboratory?

It’s no secret that scientific research laboratories around the world aren’t exactly the most eco-friendly institutions. High energy utilization, single use products, and continuous chemical consumption are among the many routine ways a laboratory can hurt the environment. However, we can proactively address improper laboratory practices to lessen their adverse impact on the environment.

What are the Best Practices of LC MS Internal Standards?

In an ideal scenario, a typical solution that is equally injected and then tested multiple times should have same signal response. In practice, however, the signal will likely vary due to different analytical conditions. These conditions include inconsistency in sample preparation, injection volume, mass spectrometer, and matrix effects. Hence, it is necessary to include an Internal Standard...

What are Matrix Effect in Liquid Chromatography Mass Spectrometry?

Matrix Effects are the suppressing or enhancing properties of a co-eluting compound from a biological matrix on the primary signal response of the target analyte. In several liquid chromatography-tandem mass spectrometry (LC-MS) biological studies, Matrix Effects can suppress the ion intensity by interfering with target analyte ionization. Compounds with high mass, polarity, and...