What is the Role of Cell-based Assays during Drug Development?
Cell-based Assays: From Drug Discovery and Preclinical to Clinical Phases
Cell based assays are extensively used in drug discovery and development, as this method provides feedback from experiments with living cells. These tests include various types of assays, some of which are already discussed above, such as toxicity assay, cell proliferation assay, motility assays, etc.
Cell based assays allow scientists to monitor cell behavior and achieve accurate quantitation of cellular pathways. Undoubtedly, the obtained insights from these experiments facilitate drug development across various phases such as discovery, preclinical, and clinical. Thus, Cell based assay development can be critical in quickly identifying potentially viable drug candidates while eliminating the need for multiple screening methods.
A few applications of Cell based assays in drug discovery and development are as under:
- Identifying antiviral and antimicrobial compounds
- Evaluating non-toxic and toxic drug substances
- Detecting viral contaminations harmful to the body
- Recognizing pathogen-associated molecular patterns (PAMPs)
- Screening pathogen recognition receptor antagonists and agonists
Cell based assays are used in measurements of various biological markers critical to drug discovery and development. At NorthEast BioLab, we implement Cell based assays using clinical and FDA-approved standards.