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                                                              • Mass Spectrometry Analysis

                                                              Trusted Mass Spectrometry Analysis Lab, Method Development, And Validation For Over 15 Years!

                                                              • Rapid Mass Spectrometry Method Development And GLP Method Validation
                                                              • Mass Spectrometry Analysis Services At Industry-Leading Turnaround
                                                              • FDA Audited Mass Spectrometry Lab For Your PK Sample Analysis And Stability Testing
                                                              • High-Value, Custom Mass Spectrometry Testing For Your Small Molecule Biomarkers
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                                                              Click below for answers to your Mass Spectrometry Analysis questions -
                                                              • What is Mass Spectrometry Analysis?
                                                                What is Mass Spectrometry Analysis?
                                                              • How is Mass Spectrometry Analysis performed?
                                                                How is Mass Spectrometry Analysis performed?
                                                              • When is Mass Spectrometry Data Analysis used?
                                                                When is Mass Spectrometry Data Analysis used?
                                                              • Why choose us for your Mass Spectrometry Data Analysis?
                                                                Why choose us for your Mass Spectrometry Data Analysis?

                                                              Ask Us About Your Study

                                                              Mass Spectrometry Analysis is performed on state-of-the-art instrumentation to achieve trustworthy drug discovery and development data. Mass Spectrometric Data Analysis helps provide crucial answers for safety and efficacy to industry and regulators alike by boosting our understanding of PK/TK/BABE parameters and proven biomarkers, etc. NorthEast BioLab has dedicated scientists, technical know-how, and several types of AB-Sciex equipment to perform your high-value Mass Spectrometry Data Analysis promptly.

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                                                              What is Mass Spectrometry Analysis?

                                                              Mass Spectrometry Analysis: Prime Platform for Expedited Bioanalysis

                                                              Mass spectrometry analysis has become an integral part of all phases of drug R&D over the last decade. It has undoubtedly accelerated the intricate, consuming, and intensive drug discovery and development process at each phase and continues to contribute invaluable insight for driving drug innovation in the right direction.Typical mass spectrometry data analysis platform for drug or biomarker testing consists of the following –

                                                              Ion Source

                                                              Here, the analyte is ionized utilizing any of the various technologies. Put differently, Ion source in the mass spectrometer is responsible for applying a charge to the analyte. Consequentially, every analyte that passes through this stage has a specific mass-to-charge ratio.

                                                              Analyzer

                                                              Next, the mass analyzer assesses the mass-to-charge values for the ions and sorts them on the basis on these values. The fundamental principles of particle physics are harnessed for the analysis – positive ions move in the direction of the negative plates at varying speeds. Heavier the molecules, lower the velocity. Furthermore, the magnetic field is used to deflect the ions at varying velocity depending upon the mass of ions.

                                                              Detector

                                                              Finally, the function of the mass detector is to count the molecules passing through the sensor with different mass-to-charge values and obtain a computerized mass spectrum.

                                                              The entire system is controlled by software that enables operating all units together, as well as acquiring and interpreting data for the final output, i.e., report on quantitative analysis of the drug.

                                                              What Our Sponsors Have to Say?

                                                              VP, Bioanalytical Development

                                                              NorthEast BioLab is by far the most responsive and thorough bioanalysis lab services CRO.

                                                              VP, Biomarker Development 

                                                              We partnered on several programs and found NorthEast BioLab responsive, collaborative, and reliable.

                                                              Executive Director, Pharmacokinetics

                                                              We trust NorthEast BioLab to design and execute the most streamlined and impactful bioanalytical projects.

                                                              President & CSO, Biotech

                                                              We found their integrity as refreshing as readiness to provide creative scientific input and high-quality data.

                                                              Sr. Associate Director, Clinical Trials

                                                              We have worked with NorthEast BioLab for over ten years given their commitment to highest quality bioanalytical data.

                                                              Co-Founder, Biotech & University PI

                                                              NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism.

                                                              VP, PK PD Analysis

                                                              NorthEast BioLab always exceeds expectations on bioanalytical assay development, validation, and sample analysis.

                                                              Head, Bioanalytical Development

                                                              NorthEast BioLab truly goes that extra mile, and we hope to continue enjoying seminal interactions with them.

                                                              Sr.Director, Bioanalytical Development & QC

                                                              NorthEast BioLab presents a science-based, hands-on, no-frills approach on the latest bioanalytical platforms.

                                                              SVP Quality & Compliance, Biotech

                                                              We are thrilled to complete our bioanalytical studies with their top quality and incredibly responsive team.

                                                              Director, PK

                                                              We worked closely to implement the most efficient and cost-effective bioanalytical assay for our PK Studies.

                                                              VP, Head of Clinical Operations

                                                              Our projects with NorthEast BioLab include successful method development, validation, stability studies during Clinical Phase I – IV studies.

                                                              Executive Director, Drug Research

                                                              NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. We highly recommend them and look forward to working together again.

                                                              Director, Bioequivalence Testing

                                                              Our latest successful study was a pivotal bioequivalence study, where samples from a cross-over study with about 100 volunteers needed swift analysis.

                                                              Head, PK

                                                              This study, same as all other bioanalytical studies with NorthEast BioLab, was completed with top quality and reporting standard with incredible responsiveness.

                                                              VP, Development Operations

                                                              As a small company, our vendors are key members of our project teams. The scientists at NorthEast BioLab are technical experts, who produce high-quality data, on-time, and on-budget.

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                                                              Explore Our Mass Spectrometry Analysis Services Lab CRO!
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                                                              How is Mass Spectrometry Analysis performed?

                                                              Mass Spectrometry Analysis: Hyphenated Techniques and Other Practices

                                                              By itself, the mass spectrometry analysis is a highly sensitive detector that becomes even more powerful when coupled with other front-end technologies, such liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), inductively coupled plasma (ICP), etc. These days mass spectrometer coupled with liquid chromatography provides a tool not only for pharmacokinetic studies studies but also proteomics, metabolomics, and genomics research.

                                                              For small molecules analysis in biological fluids, Multiple Reaction Monitoring is used to obtain highly selective detection. In multiple reactions monitoring (MRM), a parent ion is monitored in Q1 and its unique fragment ion in Q3. In some cases, it may even be necessary to modify the analyte chemically for improving the mass spectrometry analysis assay. This technique is known as chemical derivatization and is used for enhancing the selectivity and sensitivity of the analyte in mass spectrometry analysis.

                                                              Complete Guide On LC-MS: Working, Analysis & Methods

                                                              Mass spectrometry is a widely used procedure observed as having outstanding sensitivity. Triple-quadrupole mass spectrometry (MS/MS) offers additional benefits due to its selectivity. In mass spectrometry analysis, it is essential to isolate….

                                                              Read More at our Learning Center

                                                              When is Mass Spectrometry Data Analysis used?

                                                              Mass Spectrometry Data Analysis: From Drug Discovery to Clinical Trials

                                                              Discovery

                                                              Mass spectrometry analysis plays a critical role in drug discovery chemistry when thousands of compounds are tested to select the compound with the highest probability of success in becoming a drug candidate for development.

                                                              Preclinical

                                                              Once drug candidates with good bioavailability are selected, additional dose range finding (DRF) studies are performed in various animal species to enable IND filing. These Tox studies require full toxicokinetic analysis for exact measurement of the drug in rodent and non-rodent species. Mass spectrometry analysis coupled with Liquid chromatography can be used for the analysis of drugs from these studies.

                                                              Clinical

                                                              Once the drug moves into the clinical phase, mass spectrometry analysis further helps with pharmacokinetic studies related to NDA filing.

                                                              Registered And Inspected By Various Regulatory Agencies

                                                              Why choose us for your Mass Spectrometry Data Analysis?

                                                              Industry Leading Experience in Mass Spectrometry Data Analysis For Drug Discovery Development

                                                              NorthEast BioLab has outstanding capabilities for mass spectrometry analysis. Our scientists have 20+ year experience in developing and validating hundreds of LC-MS/MS methods in various biological matrices. Although mass spectrometry data analysis has become routine, laboratory staff continue to face several challenges given the continually evolving nature of the science and application in sophisticated assays. Our veteran team is adept at optimizing mass spectrometer conditions and developing robust and sensitive methods on the platform. We can guide you all the way from assay development, lead optimization, preclinical testing to clinical trials.

                                                              We offer mass spectrometry analysis based method development, transfer, validation, and sample analysis for quantitative evaluation of small molecules. Our scientists comply with Good Laboratory Practices (GLP) and Good Clinical Practices (GCP) for conducting preclinical rodent, non-rodent, and clinical studies on healthy volunteers and patients respectively. Ultimately, our expertise along with operational excellence always allows us to maintain regulatory compliance.

                                                              NorthEast BioLab adopts various client-centric approaches and collaboration techniques to accelerate your drug program. For example, structural, experimental, and functional changes are quickly forwarded with sponsor approval to avoid delays and related expenses. Furthermore, our lab scientists and analysts always remain fully transparent as our strategic partnership with clients is based out foundational values.

                                                              Questions On Our Mass Spectrometry Analysis Lab CRO Services?

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                                                              • HPLC Method Development Validation HPLC Method
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                                                              Expertise

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                                                              Services

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