sales@nebiolab.com Follow Up On Email
(203) 361 3780 Follow Up On Phone
Agile Bioanalytical Services CRO
  • Expertise
    • All Expertise
    • Mass Spectrometry (LC-MS)
      • Mass Spectrometry Services
      • HPLC Lab Services
    • Meso Scale Discovery Assay
    • ELISA Assay
      • Luminex Multiplex Assay
    • qPCR Analysis, dPCR Assay
    • LI-COR Odyssey (WB, ICW)
  • Services
    • All Services
    • Pharmacokinetics (PK) Study
      • Toxicology (Tox) Study
      • Dose Formulation Analysis
      • PK PD Analysis
      • Drug Metabolism and Pharmacokinetics (DMPK)
      • ADME Studies
      • Bioequivalence and Bioavailability Studies
    • ADA Assay, Neutralizing Antibody Assay
    • Cytokine Analysis, Biomarker Assay
      • Biomarker Assay List
    • Cell-Based Assays
      • Mechanism of Action (MOA) Studies
      • Cytotoxicity Assay
      • Biochemical Assay
    • Bioanalytical Assay Validation
  • Solutions
    • All Solutions
    • Method Development, Validation, And Transfer
      • Method Validation
      • Method Development
      • Method Transfer
    • Bioanalysis
    • GLP Laboratory
    • Clinical CRO
      • Clinical Trial Sample Management and Storage
    • Preclinical CRO
    • Analytical Testing
      • Analytical Quantitation
    • Non-GLP Testing
      • Discovery and Research
      • Cosmetic Testing
  • About Us
    • About Us
    • Overview
    • Why Us?
    • Values
    • Leadership
    • Process
    • Quality and Compliance
    • Facility and Equipment
    • Therapeutic Areas
    • Partners
    • Careers
      • GLP Quality Assurance Manager, Bioanalytical Lab
      • Sr. Scientist, ELISA Immunoassay Bioanalysis
      • Sr. Scientist, LC-MS/MS Bioanalysis – Hamden, CT, USA
      • Associate Scientist, Central Laboratory Services
      • Sr. Scientist – Pharmacokinetics (PK) Studies
      • Content Manager, Scientific and Regulatory Writing
  • Resources
    • Learning Center
    • Blog
    • Case Study
    • Video Brochures
    • News and Events
    • Testimonials
    • Contact Us
  • Request Quote
Agile Bioanalytical Services CRO Request Quote

Expertise

  • All Expertise
    • Mass Spectrometry (LC-MS)
      • Mass Spectrometry Services
      • HPLC Lab Services
    • Meso Scale Discovery Assay
      • ELISA Assay
        • Luminex Multiplex Assay
      • qPCR Analysis, dPCR Assay
        • LI-COR Odyssey (WB, ICW)

          Services

          • All Services
            • Pharmacokinetics (PK) Study
              • Toxicology (Tox) Study
              • Dose Formulation Analysis
              • PK PD Analysis
              • Drug Metabolism and Pharmacokinetics (DMPK)
              • ADME Studies
              • Bioequivalence and Bioavailability Studies
            • ADA Assay, Neutralizing Antibody Assay
              • Cytokine Analysis, Biomarker Assay
                • Biomarker Assay List
              • Cell-Based Assays
                • Mechanism of Action (MOA) Studies
                • Cytotoxicity Assay
                • Biochemical Assay
              • Bioanalytical Assay Validation

                Solutions

                • All Solutions
                  • Method Development, Validation, And Transfer
                    • Method Validation
                    • Method Development
                    • Method Transfer
                  • Bioanalysis
                    • GLP Laboratory
                      • Clinical CRO
                        • Clinical Trial Sample Management and Storage
                      • Preclinical CRO
                        • Analytical Testing
                          • Analytical Quantitation
                        • Non-GLP Testing
                          • Discovery and Research
                          • Cosmetic Testing

                        About Us

                        • About Us
                          • Overview
                            • Why Us?
                              • Values
                                • Leadership
                                  • Process
                                    • Quality and Compliance
                                      • Facility and Equipment
                                        • Therapeutic Areas
                                          • Partners
                                            • Careers
                                              • GLP Quality Assurance Manager, Bioanalytical Lab
                                              • Sr. Scientist, ELISA Immunoassay Bioanalysis
                                              • Sr. Scientist, LC-MS/MS Bioanalysis – Hamden, CT, USA
                                              • Associate Scientist, Central Laboratory Services
                                              • Sr. Scientist - Pharmacokinetics (PK) Studies
                                              • Content Manager, Scientific and Regulatory Writing

                                            Resources

                                            • Learning Center
                                              • Blog
                                                • Case Study
                                                  • Video Brochures
                                                    • News and Events
                                                      • Testimonials
                                                        • Contact Us

                                                          Request Quote

                                                            Contact Us

                                                            NorthEast BioLab Logo Agile Bioanalysis Services CRO
                                                            Request Quote Contact Us
                                                            • Home
                                                            • BDNF Biomarker Assay Testing

                                                            Brain-Derived Neurotrophic Factor

                                                            • Brain-Derived Neurotrophic Factor (BDNF) is a member of neurotropin-family of proteins
                                                            • BDNF promotes survival, growth and differentiation of neurons and synapses in central and peripheral nervous system
                                                            • BDNF serves as a biomarker of neurological conditions like schizophrenia and depression
                                                            • BDNF can be assayed using ELISA, MSD or Luminex

                                                            Good Laboratory Practice for Nonclinical Laboratory StudiesFood and Drug Administration (FDA)

                                                            Provide Your Bioanalysis Study Details

                                                            We Will Respond Within 1 Business Day

                                                            Lab
                                                            Click below for answers to your BDNF Biomarker Study questions -
                                                            • What is BDNF?
                                                              What is BDNF?
                                                            • What are BDNF Functions and Effects?
                                                              What are BDNF Functions and Effects?
                                                            • How do we perform BDNF lab test?
                                                              How do we perform BDNF lab test?
                                                            • Where could I learn more about BDNF Assay?
                                                              Where could I learn more about BDNF Assay?

                                                            What is BDNF?

                                                            An Introduction to Brain-Derived Neurotrophic Factor (BDNF)

                                                            Brain-Derived Neurotrophic Factor (BDNF) is a protein encoded by the BDNF gene in humans. It supports the survival of neurons in the central and peripheral nervous systems. BDNF functions as a neurotransmitter modulator and engages in neuronal plasticity. BDNF protein encourages the growth and maturation (differentiation) of new neurons and synapses. BDNF biomarker has been detected in the hippocampus, cortex, and basal forebrain, areas of brain responsible for learning, memory, and higher thinking. BDNF protein is also detectable in the kidneys, retina, motor neurons, saliva, and skeletal muscle . When searching for ‘What is BDNF’, you can also search for its aliases – Abreneurin, ANON2, and BULN2.

                                                            Sponsors Love Our Bioanalytical Laboratory Services For Top Quality And Industry Leading Turnaround

                                                            Connect With Us For A Reference Call With Them!

                                                            VP, Bioanalytical Development

                                                            NorthEast BioLab is by far the most responsive and thorough bioanalysis lab services CRO.

                                                            VP, Biomarker Development 

                                                            We partnered on several programs and found NorthEast BioLab responsive, collaborative, and reliable.

                                                            Executive Director, Pharmacokinetics

                                                            We trust NorthEast BioLab to design and execute the most streamlined and impactful bioanalytical projects.

                                                            President & CSO, Biotech

                                                            We found their integrity as refreshing as readiness to provide creative scientific input and high-quality data.

                                                            Sr. Associate Dir., Clinical Trials

                                                            We have worked with NorthEast BioLab for over ten years given their commitment to highest quality bioanalytical data.

                                                            Co-Founder, Biotech & University PI

                                                            NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism.

                                                            VP, PK PD Analysis

                                                            NorthEast BioLab always exceeds expectations on bioanalytical assay development, validation, and sample analysis.

                                                            Head, Bioanalytical Development

                                                            NorthEast BioLab truly goes that extra mile, and we hope to continue enjoying seminal interactions with them.

                                                            Sr. Dir., Bioanalytical Development & QC

                                                            NorthEast BioLab presents a science-based, hands-on, no-frills approach on the latest bioanalytical platforms.

                                                            SVP Quality & Compliance, Biotech

                                                            We are thrilled to complete our bioanalytical studies with their top quality and incredibly responsive team.

                                                            Director, PK

                                                            We worked closely to implement the most efficient and cost-effective bioanalytical assay for our PK Studies.

                                                            VP, Head of Clinical Operations

                                                            Our projects with NorthEast BioLab include successful method development, validation, stability studies during Clinical Phase I – IV studies.

                                                            Executive Director, Drug Research

                                                            NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. We highly recommend them and look forward to working together again.

                                                            Dir., Bioequivalence Testing

                                                            Our latest successful study was a pivotal bioequivalence study, where samples from a cross-over study with about 100 volunteers needed swift analysis.

                                                            Head, PK

                                                            This study, same as all other bioanalytical studies with NorthEast BioLab, was completed with top quality and reporting standard with incredible responsiveness.

                                                            VP, Development Operations

                                                            As a small company, our vendors are key members of our project teams. The scientists at NorthEast BioLab are technical experts, who produce high-quality data, on-time, and on-budget.

                                                            Ready to Take the First Step?

                                                            Consult with a Scientist About Your BDNF Biomarker Assay Study
                                                            SPEAK TO OUR SCIENTISTS
                                                            EGF Functions and Effects

                                                            What are BDNF Functions and Effects?

                                                            Understanding the functions and effects of BDNF

                                                            Brain-Derived Neurotrophic factor is vital for long-term memory. The brain retains the capability of neurogenesis which is the capability to grow neurons from stem cells, even though most human neurons have prenatal formation. BDNF biomarker is one of the neurotropin, which are proteins that aid the stimulation of neurogenesis. Other researched BDNF functions and effects include synaptic plasticity, inflammation and immunity, growth of cardiac and endothelial cells, lipid metabolism, etc. Specific exercises, such as treadmill in mice and aerobics in humans, are considered to increase BDNF growth factors.

                                                            Drug Discovery and Development Process

                                                            How long do you think it takes for a new drug to get approved in the US? About 12-15 years, that’s roughly 1/3rd duration of the entire professional career for any of us. Next, how much investment do you think is required to bring a new drug to market?

                                                            Read More at our Learning Center
                                                            Drug Discovery And Development Process

                                                            How do we perform BDNF lab test?

                                                            Protocols we follow to perform BDNF tests

                                                            BDNF level considered normal in humans and other species is an area of active biological research. At NorthEast BioLab, we tailor BDNF testing to suit your desired assay parameters through BDNF MSD, Luminex, and ELISA. Typically, these BDNF assays employ the fundamentals of the quantitative sandwich enzyme immunoassay technique explained below.
                                                            First, we pre-coat the antibody specific to capture BDNF biomarker onto a microplate and follow up by a plate wash to remove any unbound substances. Next, calibration standards, quality controls, and biological samples get pipetted into the plate wells, and the immobilized capture antibody binds any BDNF present. Then, we wash off any unbound material following proper shaking and incubation as per method protocol. Later, a biotin-conjugated antibody specific for BDNF detection gets added to the wells· After washing, we add avidin conjugated Horseradish Peroxidase (HRP) to the plate wells and rinse again to remove any unbound avidin-enzyme reagent. Eventually, we add a substrate solution to the plate wells, and color develops in proportion to the amount of BDNF bound in the initial step. The final step in BDNF ELISA requires us to halt the color development and quantitate the color intensity with a suitable plate reader.

                                                            Over the years, NorthEast Biolab has acquired the experience to reproduce high-quality BDNF assays. Our scientists and researchers can perform BDNF assay to measure the analyte in multiple formats. We have extensive expertise on BDNF assay specifics, such as matrix type, tissue lysis, volume requirements, sample dilution, and multiplexing possibilities. Our scientists rely only on preapproved vendors and recommended kits, antibodies, diluents, buffers, substrates, reagents, calibrators, control matrices, etc. for running BDNF Luminex and MSD Assay. We follow the industry best practices to ensure accuracy and test your biomarkers through high-affinity materials. Our focus on efficiency and operational excellence helps us deliver high-quality BDNF testing services to all our sponsors.

                                                            EGF lab test

                                                            Registered And Inspected By Various Regulatory Agencies

                                                            learn more about EGF Assay

                                                            Where could I learn more about BDNF Assay?

                                                            Popular BDNF resources for you to explore

                                                            Numerous publications have associated BDNF biomarker levels with conditions affecting various brain functions. Some of these include depression, schizophrenia, obsessive-compulsive disorder, Alzheimer’s disease, Huntington’s disease, Rett syndrome, dementia, and anorexia nervosa and bulimia nervosa neurodegeneration. Increasingly, literature illustrates the considerable interest in the presence of brain-derived neurotrophic factor (BDNF) in human blood.

                                                            Here are some resources for you to read further on the BDNF protein:
                                                            https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504526/
                                                            https://ghr.nlm.nih.gov/gene/BDNF
                                                            https://elifesciences.org/articles/15092/
                                                            https://www.sciencedirect.com/topics/medicine-and-dentistry/brain-derived-neurotrophic-factor/

                                                            Explore More Biomarkers

                                                            • Brain-Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor
                                                            • Granulate Colony Stimulation Factor Granulate Colony Stimulation Factor
                                                            • Epidermal growth factor Epidermal growth factor
                                                            • Fas Ligand Fas Ligand
                                                            • Granulocyte Macrophage Colony Stimulating Factor Granulocyte Macrophage Colony Stimulating Factor
                                                            • Leukemia Inhibitory Factor Leukemia Inhibitory Factor
                                                            • Luteinizing hormone Luteinizing hormone
                                                            • Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor
                                                            • Interferon Beta Interferon Beta
                                                            • Interferon Gamma Interferon Gamma
                                                            • Transforming Growth Factor Beta 1 Transforming Growth Factor Beta 1
                                                            • B Type Natriuretic Peptide B Type Natriuretic Peptide
                                                            • Glial Fibrillary Acidic Protein Glial Fibrillary Acidic Protein
                                                            • Cystatin C Cystatin C
                                                            • Hepatocyte Growth Factor Hepatocyte Growth Factor
                                                            • Interferon Alpha 2 Interferon Alpha 2
                                                            • Tumor Necrosis Factor Alpha Tumor Necrosis Factor Alpha

                                                            Expertise

                                                            • Mass Spectrometry (LC-MS)
                                                            • Meso Scale Discovery Assay
                                                            • ELISA Assay
                                                            • qPCR Analysis, dPCR Assay
                                                            • LI-COR Odyssey (WB, ICW)

                                                            Services

                                                            • Pharmacokinetics (PK) Study
                                                            • ADA Assay, Neutralizing Antibody Assay
                                                            • Cytokine Analysis, Biomarker Assay
                                                            • Cell-Based Assay
                                                            • Bioanalytical Assay Validation

                                                            Solutions

                                                            • Method Development, Validation, And Transfer
                                                            • Bioanalysis
                                                            • GLP Laboratory
                                                            • Clinical CRO
                                                            • Preclinical CRO
                                                            • Analytical Testing
                                                            • Non-GLP Testing

                                                            About Us

                                                            • Overview
                                                            • Why Us?
                                                            • Values
                                                            • Leadership
                                                            • Process
                                                            • Quality and Compliance
                                                            • Facility and Equipment
                                                            • Therapeutic Areas
                                                            • Partners
                                                            • Careers

                                                            Resources

                                                            • Learning Center
                                                            • Blog
                                                            • Case Study
                                                            • Video Brochures
                                                            • News and Events
                                                            • Testimonials
                                                            • Contact Us
                                                            NorthEast BioLab Logo

                                                            35 Worth Ave, Hamden, CT 06518

                                                            sales@nebiolab.comFollow Up On Email
                                                            (203) 361 3780Follow Up On Phone

                                                            Contact A Scientist With Your Bioanalytical Study Details

                                                            We Will Respond Within 1 Business Day

                                                            • Good Laboratory Practice for Nonclinical Laboratory Studies
                                                            • Food and Drug Administration (FDA)
                                                            • United States Drug Enforcement Administration
                                                            • Connecticut State Department of Consumer Protection
                                                            • Privacy Policy
                                                            • Terms of Use
                                                            • Sitemap
                                                            © 2019 - 2025, NorthEast BioAnalytical Laboratories LLC. All rights reserved.

                                                            How Can We Help?

                                                            I agree to receive emails, calls, and messages, etc from NorthEast BioLab.

                                                            Before you go! Get
                                                            your FREE Download:

                                                            Top 7 Hidden Pitfalls to your Bioanalytical Milestones

                                                            Step by step guide on how to accelerate your drug approval

                                                            • Addressing Main Constraints
                                                            • Research Best Practices
                                                            • The Economic Advantage
                                                            • Critical Decision Marketing Mode Easy
                                                            • Legal Documentation Checklist
                                                            We won’t share your email, ever, See our privacy policy

                                                            No thanks, I don’t need to improve my drug approval process