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About UsOverviewLeadershipFacility and EquipmentQuality and ComplianceTherapeutic AreasWhy Us?ValuesProcessPartnersCareers
Discovery & Screening uses high-throughput and cell-based assays to identify drug candidates, assess biological activity, and evaluate therapeutic potential efficiently. These techniques enable rapid analysis of large data sets for faster drug development. Cell-based screening plays a pivotal role in drug discovery assays, offering a more physiologically relevant approach to studying drug efficacy and safety.
Discovery & Screening services use advanced technology to support drug discovery and research. Cell-based, phenotypic, and compound screening help identify drug targets and promising compounds efficiently. These methods accelerate drug development by providing detailed biological insights.
For over two decades, NorthEast BioLab has been a trusted provider of tailored Discovery & Screening solutions, helping clients navigate the complexities of drug research with precision and expertise.
Discovery & Screening accelerates drug R&D, from target identification to in vivo screening, ensuring efficacy and safety. High-throughput drug screening streamlines drug development, driving innovation in pharma and biotech.
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“NorthEast BioLab is the most responsive and thorough bioanalysis lab services CRO.”
“NorthEast BioLab is a responsive, collaborative, and reliable partner.”
“We trust NorthEast BioLab to design and execute streamlined, impactful bioanalytical projects.”
We found their integrity as refreshing as readiness to provide creative scientific input and high-quality data.
We have worked with NorthEast BioLab for over ten years given their commitment to highest quality bioanalytical data.
NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism.
NorthEast BioLab always exceeds expectations on bioanalytical assay development, validation, and sample analysis.
“NorthEast BioLab goes the extra mile. We look forward to more meaningful collaborations.”
“NorthEast BioLab offers a science-based, hands-on approach to the latest bioanalytical platforms.”
We are thrilled to complete our bioanalytical studies with their top quality and incredibly responsive team.
We worked closely to implement the most efficient and cost-effective bioanalytical assay for our PK Studies.
Our projects with NorthEast BioLab include successful method development, validation, stability studies during Clinical Phase I – IV studies.
NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. We highly recommend them and look forward to working together again.
Our latest successful study was a pivotal bioequivalence study, where samples from a cross-over study with about 100 volunteers needed swift analysis.
This study, same as all other bioanalytical studies, was completed with top quality and reporting standard with incredible responsiveness.
“NorthEast BioLab’s scientists deliver high-quality data on time and within budget.”
At our cutting-edge lab, we offer an extensive range of Discovery & Screening services to enhance your drug target identification, pharmacological screening, and early-stage drug discovery assays.
Our services include:
With 20+ years of expertise, we’ve executed hundreds of high-throughput assays and high throughput screening drug discovery services, ensuring precise and efficient outcomes. Our advanced screening technologies deliver
high sensitivity and accuracy for drug discovery.
At NorthEast BioLab, we follow GLP and GCP standards, ensuring compliance with FDA and EMA regulations. Our processes support reliable regulatory submissions for drug discovery and development.
We tailor our Discovery & Screening services to your specific goals, ensuring transparency and flexibility. Our team keeps you informed at every stage, prioritizing your success. With expert guidance, we help you navigate complex drug discovery challenges.
Partner with us for Discovery & Screening to advance your drug discovery projects. Contact us today to achieve breakthrough results in your research.
Drug development is a massive undertaking and selecting responsive partners, who prioritize in sync with you for your new drug approval and focus on high quality and fast turnaround.
Discovery & Screening employs cutting-edge techniques to identify, evaluate, and optimize potential drug candidates. These processes leverage a combination of high-throughput screening assays, phenotypic screening in drug discovery, and cell-based drug screening methods to analyze biological responses and identify promising therapeutic targets. Phenotypic screening in drug discovery identifies compounds that produce desired cellular effects, enabling novel therapeutic discoveries without prior target knowledge.
Screening methods combine compound library screening and high-throughput compound screening to efficiently evaluate thousands of compounds for potential pharmacological effects.
Target engagement assays confirm compound-target interactions, while in vivo drug screening provides insights into therapeutic viability and safety. By integrating in vivo drug screening with advanced analytical methods, researchers gain a comprehensive understanding of a compound's therapeutic viability and safety profile.
The choice of techniques depends on the research goals. For instance, pharmacological screening may focus on identifying bioactivity, while cell-based screening emphasizes functional responses in a physiological context.
Discovery & Screening drive drug development by enabling efficient drug target identification, evaluation, and optimization. Its versatility supports breakthroughs in pharmacology, biotechnology, and therapeutic research.
Answers to additional Discovery Screening Services questions popular among our potential clients.
Screening in drug discovery tests large libraries of chemical compounds to identify those with potential biological activity against a specific target. Techniques like high-throughput and cell-based screening efficiently evaluate compounds, narrowing down options with therapeutic potential.
The four stages include:
Drug discovery involves identifying and developing new compounds to treat diseases. This process includes understanding disease mechanisms, identifying targets, screening compounds, and optimizing candidates into safe, effective treatments.
Drug screening systematically evaluates substances to identify those with therapeutic potential. High-throughput screening and cell-based assays help analyze many compounds and understand their physiological effects.
The five pillars are:
There are four main stages:
Drug discovery includes:
The four stages are:
High-throughput screening (HTS) plays a crucial role in drug discovery by enabling the rapid testing of thousands of compounds to identify those with potential biological activity. This technology automates the screening process, providing high-efficiency and high-accuracy results, which accelerates the early stages of drug development.
Cell-based screening evaluates compounds within a living cell environment, providing insights into their functional effects and physiological relevance. Biochemical screening, on the other hand, focuses on direct interactions between a compound and a target in a controlled environment outside of cells, such as enzymatic activity assays. Cell-based methods are particularly valuable for studying complex biological processes.
Phenotypic screening is a method used in drug discovery to identify compounds that produce desired effects on cells or organisms without prior knowledge of the target. It is important because it allows for the discovery of novel therapeutic mechanisms and pathways, broadening the scope for innovative drug development.
Compound library screening involves testing a diverse collection of chemical compounds against a specific biological target or system to identify those with potential therapeutic effects. This process uses automated systems, high-throughput assays, and advanced analytical methods to evaluate thousands of compounds efficiently.
Discovery & Screening services support early drug development by identifying and optimizing lead compounds, evaluating their biological activity, and ensuring their safety and efficacy. These services employ advanced techniques such as target engagement assays and in vivo screening to provide actionable insights for further development.
Discovery & Screening utilizes a variety of advanced technologies, including high-throughput screening, cell-based assays, compound library screening, and phenotypic screening. These tools enable efficient data generation and analysis, accelerating the drug discovery process.
Target engagement assays are used to confirm the direct interaction between a drug candidate and its biological target. These assays provide critical insights into the compound’s mechanism of action, helping researchers evaluate its therapeutic potential and refine its properties during the drug discovery process.
Regulatory compliance ensures Discovery & Screening services meet the highest industry standards, such as Good Laboratory Practices (GLP) and Good Clinical Practices (GCP). Compliance is essential for generating reliable data, supporting regulatory submissions, and advancing drug candidates through development.
Customized screening solutions are designed to address specific research goals and challenges. These tailored approaches optimize screening processes, improve accuracy, and ensure the data generated is relevant and actionable for advancing drug development projects.
Key challenges include managing the complexity of biological systems, ensuring data quality and reproducibility, identifying off-target effects, and balancing speed with accuracy in high-throughput methods. Addressing these challenges requires advanced technology and expertise.
In vivo drug screening involves testing potential drug candidates in live organisms to evaluate their therapeutic effects, safety, and pharmacokinetics in a more complex biological system. It is typically used after in vitro assays to validate the efficacy and safety of lead compounds.
Discovery & Screening services lay the foundation for clinical development by identifying and optimizing drug candidates with favorable profiles. The insights generated during these stages help design clinical trials, ensuring that only the most promising candidates advance.
Discovery & Screening services are essential for biotech companies because they provide the expertise, technology, and resources needed to accelerate drug development. These services enable companies to efficiently identify potential therapies, optimize compounds, and bring innovative treatments to market faster.
