What are the various Immunogenicity ADA Assays Offered by Us?
Immunogenicity ADA Assays by NorthEast BioLab
Immunogenicity assays are critical in measuring an immune response against the therapeutic proteins. These tests also measure the various anti-drug antibodies (ADA) and soluble protein biomarkers. The findings from these measurements impact dose selection and the safety profile of the drug. The soluble protein biomarkers quantified during ADA assay can reveal target engagement, provide a mechanism of action, and predict the immune response related to the drug.
Samples for immunogenicity assay contain complex matrices that can create considerable interference and cause inaccuracies. Hence, scientists formulate strategies to reduce interference in immunogenicity testing and accurately support the development of therapeutic antibodies and other drug candidates.
NorthEast Biolab has 15+ years of experience in designing, optimizing, and validating ADA assays for biotech and pharma companies. We implement GLP and GCP evaluation of a new biologics in preclinical and clinical stages, respectively. Our veteran scientists have worked on a variety of immunogenicity testing assay to provide highly sensitive and selective methods.
Our services include the following procedures, at all stages of the immunogenicity assay development process:
- Purification, modification, and procurement of antibodies
- Immunogen and antigen preparation
- Cell line formation
- Development and optimization of immunoassays
- Reagent preparation
- Anti-drug antibody screening
- Titration and isotyping