Discovery and Research Biology
Target identification and validation
- Small interfering RNA (siRNA) and gain-of-function studies
Assay development
- Biochemical assays with expression and purification of proteins
- Stable mammalian cell line generation
- Molecular Biology, including cloning, mutant generation etc.
Lead optimization
- “Mechanism of action”, including pathway identification
- Compound profiling and pharmacology – early efficacy, safety, and toxicity
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