Target identification and validation

  • Metabolic activity and functional behavior of biomolecules
  • Protein-protein, protein-RNA, and protein-DNA interactions
  • Small interfering RNA (siRNA) and gain-of-function studies

Assay development

  • Biochemical assays with expression and purification of proteins
  • Molecular Biology, including cloning, mutant generation, etc.
  • Stable mammalian cell line generation

Lead optimization

  • “Mechanism of action”, including pathway identification
  • Compound profiling and pharmacology – early efficacy, safety, and toxicity