Discovery and Research Biology

Target identification and validation

• Small interfering RNA (siRNA) and gain-of-function studies

Assay development

• Biochemical assays with expression and purification of proteins
• Stable mammalian cell line generation
• Molecular Biology, including cloning, mutant generation etc.

Lead optimization

• “Mechanism of action”, including pathway identification
• Compound profiling and pharmacology – early efficacy, safety, and toxicity