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Discovery and Research Biology

Target identification and validation

  • Small interfering RNA (siRNA) and gain-of-function studies

Assay development

  • Biochemical assays with expression and purification of proteins
  • Stable mammalian cell line generation
  • Molecular Biology, including cloning, mutant generation etc.

Lead optimization

  • “Mechanism of action”, including pathway identification
  • Compound profiling and pharmacology – early efficacy, safety, and toxicity