Comprehensive Mechanism of Action (MOA) Studies of Biochemical Interactions by your Drug to produce its Pharmacological Effect
The mechanism of action of a small molecule therapeutic gets clarified by studying the biochemical reactions that lead to its pharmacological effect. Mechanism of action or MOA studies are used to achieve a deeper understanding of molecular targets and identify proteins plus activated pathways in the presence of a small molecule.
The MOA can occur on the cell membrane, within the cell, or outside the cell. Since molecular targets bind to receptors, enzymes, or ion channel at the target site, the MOA can either be receptor mediated or non-receptor mediated. A receptor mediated event occurs when a drug substance binds with its receptor and produces a drug receptor complex that triggers a biological response. A non-receptor mediated pathway occurs when a drug substance activates biological reactions through other mechanisms. Typically, chemical and physical actions such as chelation and osmosis are used to determine the relevant therapeutic impact.
NorthEast BioLab is by far the most responsive and thorough bioanalysis lab services CRO.
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We have worked with NorthEast BioLab for over ten years given their commitment to highest quality bioanalytical data.
NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism.
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NorthEast BioLab truly goes that extra mile, and we hope to continue enjoying seminal interactions with them.
NorthEast BioLab presents a science-based, hands-on, no-frills approach on the latest bioanalytical platforms.
We are thrilled to complete our bioanalytical studies with their top quality and incredibly responsive team.
We worked closely to implement the most efficient and cost-effective bioanalytical assay for our PK Studies.
Our projects with NorthEast BioLab include successful method development, validation, stability studies during Clinical Phase I – IV studies.
NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. We highly recommend them and look forward to working together again.
Our latest successful study was a pivotal bioequivalence study, where samples from a cross-over study with about 100 volunteers needed swift analysis.
This study, same as all other bioanalytical studies with NorthEast BioLab, was completed with top quality and reporting standard with incredible responsiveness.
As a small company, our vendors are key members of our project teams. The scientists at NorthEast BioLab are technical experts, who produce high-quality data, on-time, and on-budget.
A clear understanding of the mechanism of action of drug compounds is necessary for drug development and prevents failure at a later stage in the approval process. MOA studies help determine the clinical safety and act as a benchmark for newer drugs before their release in the market.
There are several reasons to understand the mechanism of action, a few of which are explained below:
Bioanalysis is an essential tool in drug discovery and development for determining the concentration of drugs and their metabolites as well as various pharmacodynamics biomarkers in biological fluids. In these analyses, scientists use developed an….
Mechanism of action studies assist in identifying the target pathway of specific drug compounds. Thus, helping in the development of an efficient drug dosage regimen and minimizing off-target effects. At NorthEast BioLab, we offer MOA studies for robust lead optimization.
NorthEast BioLab experts conduct MOA studies for achieving target-specific inhibition of many cellular substrates such as signaling kinases. The process involves treating cells with compounds at different concentrations, preparing cell extracts, and quantifying protein levels through Western blots and ELISA assays.
NorthEast BioLab scientists help with compound profiling to ensure that target activities of the drug compounds minimize toxicity. Using this MOA procedure, we can identify the efficacy and safety profile of a particular drug compound.
We, at NorthEast BioLab, understand the significance of MOA studies during drug discovery and development. Similar to other drug development methods, MOA studies are crucial to find the optimal dose and minimize the harmful impact of the drug compound. Hence, our team of scientists uses the highest level industry standards to conduct these studies for efficient and valuable lead optimization.
At our laboratories, we adhere to the compliance structure and guided procedures suggested by the FDA. You can count on us for innovation and rigor in understanding the biochemical reactions activated by drug compounds, without compromising safety requirements and FDA regulations. Further, our lead optimization processes involve compound profiling to identify and minimize toxicity. After the successful execution of several sub-tasks falling under MOA studies, we can establish a safe dosage regimen, improving the chances of your drug success.
