Which Cell Based Assay Services, Cell Based Bioassay Services, Or Cell Culture Services Do We Offer?
Discover Our Comprehensive Suite Of Cell Based Assay Services, Cell Based Bioassay Services, Or Cell Culture Services To Expedite Your Drug Development And Discovery!
High Throughput Screening Service For Hit/Lead/Drug Development And Discovery
- Swift And Reliable Cell Based Bioassay Service To Screen Drug Candidates On Human Primary Cells, Stem Cells (iPSC), CRISPR-Engineered Cells, Etc.
- High Throughput Assays, Cell Viability Assays, Cell Permeability Assays, Cell Function Assays, Cell Migration Assays, Cell Invasion Assays, Cell Differentiation Assays, Etc.
- Advanced Platforms, Such As Co-Cultures, Flow Cytometry, To Mimic The Cellular Environment And Capture Complexity Of Biological Systems
In Vitro Toxicology, Toxicity Assay Service For Drug Safety
- Cell Health Assay Services: Cytotoxicity Assays, Genotoxicity Assays, Apoptosis Assays, Hepatotoxicity Assays, Necrosis Assays, Autophagy Assays, and Neurotoxicity Assays, Using Various Cell Types and Endpoints to Measure Cell Viability, DNA Damage, Cell Death, Liver Function, Inflammation, and Neuronal Function
- Cell Injury Assay Services: Mitochondrial Toxicity Assays, Hemolysis Assays, Pyrogenicity Assays, Sensitization Assays, Irritation Assays, Carcinogenicity Assays, Endoplasmic Reticulum Stress Assays, Cell Membrane Integrity Assays, Enzyme Leakage Assays, Immunotoxicity Assays, and Inflammation Assays, Using Various Methods and Indicators to Measure Cell Damage, Immune Response, and Tissue Injuries
Tailored In-Vitro Target Validation Service For Drug Efficacy And Therapeutic Benefits
- Confirm Drug Compound Target Affinity, Cellular Penetration, And Establish/Confirm Mechanism Of Action (MOA) Using Various Methods, Such As Fluorescence, Luminescence, Bioluminescence Resonance Energy Transfer (BRET), Fluorescence Resonance Energy Transfer (FRET), And Enzyme-Linked Immunosorbent Assay (ELISA).
- Create Custom Cell Lines Expressing Target With A Suitable Reporter Or Tag And Demonstrate Drug Compound Target Protein Interaction, Compound-Target Residence Time, And Binding Kinetics To Validate Your Drug Targets And Candidates, As Well As Optimize Potency And Selectivity.
Purpose-Built, Functional, In Vitro Biochemical Assay Service For Novel Drug Modalities
- Customized Biochemical Assays, Enzyme Assays, Receptor Assays, GPCR Assays, Oxidative Stress Assays, DNA Damage Assays, Protein-Protein Interaction Assays, And More For Insights Into Mechanism Of Action, Potency, Selectivity, And Pharmacodynamics Of Drug Candidates and Biomarkers.
- Multi-Platform Detection By Fluorescence Polarization Assays, TR-FRET (HTRF) Assays, BRET Assays, AlphaLISA Assays, Colorimetric Assays, and More, For High Sensitivity, Specificity, and Dynamic Range as You Optimize Drug Discovery and Development And Assess Efficacy and Safety of Your Drug Candidates and Biomarkers.
Tailored Mechanism Of Action (MoA) Assay Service For Drug Discovery And Pharmacodynamic Assessments
- Fit-for-Purpose (MoA) Assay Service to Measure Enzymatic or Kinase Activity, Cell Signaling, Gene Silencing, RNA Interference, or Other Cellular Mechanisms
- Comprehensive Cell Based ELISA Service Supporting Fluorescence, Luminescence, Absorbance, or Electrochemiluminescence, Performed in Various Formats, Such as Microplates, Microfluidics, or Biosensors.
- Custom Cell Based Assay Services to Measure Cell Death, Cell Cycle, Cell Migration, Cell Invasion, and Cell Morphology Assays, Using Diverse Platforms, Such as Flow Cytometry, Microscopy, Image Analysis, Cell Counting, and More.
Biologically Relevant, Cell Based Immunogenicity Testing Service For MAbs, Vaccines, Cell And Gene Therapies
- Plate Based or Cell-Based Neutralizing Antibody Assay Services for Assessing Anti-Drug Antibodies (ADA) to Inhibit the Biological Activity of the Drug in Vitro Using Various Detection Methods Such as ELISA, Meso Scale Discovery, Flow Cytometry, Cell Proliferation, Cytotoxicity, and Cell Viability Assays on Custom Cell Lines Expressing Target With a Suitable Reporter or Tag
- Cellular Immunogenicity Assay Services, Including Inflammatory Cytokine/Chemokine Assays in Cell Culture Media, Cell Lysates, Antibody Dependent Cell-Mediated Cytotoxicity Assays (ADCC), Complement-Dependent Cytotoxicity Assays (CDC) to Help Detect and Quantify Immune Response Induced by Your Drug Candidates in Various Cell Matrices, Such as Human Peripheral Blood Mononuclear Cells (PBMCs).
DMPK/ADME Assay Service For Drug Discovery
- In Vitro Metabolism Assay Services: CYP Inhibition, Cytochrome P450 Induction, Hepatocyte/Microsomal/S9/Plasma Stability, And Metabolite Profiling To Evaluate The Pharmacokinetics And Drug-Drug Interactions Using Metabolic Pathways, Stability, And Clearance Of Drugs In Various Biological Matrices.
- In Vitro Transcellular Permeability And Transporter Assay Services: Caco-2, PAMPA, And MDCK-MDR1 Permeability Assessment, P-gp And BCRP Inhibition And Substrate Identification Testing, SLC Transporter Substrate Identification And Inhibition Assays (OATP, OAT, OCT, And MATE) To Predict Absorption, Tissue Distribution, Or Bioavailability Of Drugs Across Biological Barriers, Such As Intestinal Epithelium, Blood-Brain Barrier, And Kidney Tubules.
Biomarker Discovery Services For Diagnosis, Prognosis, Monitoring Disease Or Therapy
- Custom Biomarker Discovery Services to Support Protein Expression Assays, Gene Incorporation Assays, Gene Expression Assays, Epigenetic Assays, microRNA Expression Assays, Cell Signaling Assays, and Cellular Phenotyping to Measure the Levels, Activity, or Function of Proteins, Genes, or Cells That Are Relevant to Your Disease of Interest.
- In Vitro Assay Services to Assist With Enzyme Activity Assays, Kinase Activity Assays, Protein-Protein Interaction Assays, Proteolysis Assays, and Other Biomarker Assays That Can Help You Study the Molecular Mechanisms and Pathways Involved in Your Disease or Treatment.