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20+ Years Of Bioanalysis
700+ Small/Large Molecule Studies
450+ Custom Bioanalytical Assays
200+ Investigational Drugs
1,000+ Biomarker & Cytokine Assays

Which Multiplex Cytokine Assay Service, Cytokine Profiling Service Do We Offer?

Customized Multiplex Cytokine Assays, Cytokine Release Syndrome (CRS) Evaluation, and Quantitative Cytokine Profiling To Assess Inflammatory Responses And Support Therapeutic Development

Multiple Platform Assay Lab Support For Cytokine Testing Services

  • Cytokine Assay Development, Validation, And Sample Analysis Using Elisa, Meso Scale Discovery, Luminex, qPCR, dPCR, Western Blot, Flow Cytometry, LC-MS, HPLC-UV, And More.
  • Ultra-Sensitive Assay Development Is Available In Singleplex Or Multiplex Formats To Support Cytokine Release Syndrome (CRS) Studies, Inflammatory Response Analysis, Pharmacodynamics, And Mechanism Of Action Investigations, With Reliable Multiplex Testing For Optimized Data Accuracy. Our Cytokine Testing Services Also Include Pro-Inflammatory Cytokine Analysis To Identify Markers Of Immune Activation And Inflammation, Ensuring Reliable Multiplex Testing For Optimized Data Accuracy

Customized, Multiplex Biomarker Assay Development In Biological Or Formulation Matrices

  • High-Sensitivity And Specific Cytokine Panel Assay Development On Meso Scale Or Luminex Platforms Using Commercially Available Assay Kits Or Antibody Pairs, With In-House Conjugation Services Available. Our Multiplex Testing Ensures Accuracy Across Various Sample Types, Including Plasma, Serum, Cell Culture Supernatants, And PBMC Isolates, Enabling Precise Analysis Of Pro-Inflammatory Cytokines.
  • Assay Development Suitable For Various Biological Or Formulation Matrices—Including Plasma, Serum, Cell Culture Supernatants, Pbmc, Urine, Tissue Lysates, Cell Lysates, And Cerebrospinal Fluid (CSF). Our Cytokine Quantification Capabilities Enhance Assay Sensitivity And Reliability.

Fit-For-Purpose GLP Cytokine Assay Validation

  • GLP Cytokine Panel Assay Validation Is Conducted In Accordance With GLP Guidelines, Using Accredited Equipment And High-Quality Reagents For Regulated Cytokine Bioanalysis. Our Multiplex Testing Protocols Are Aligned With Regulatory Standards To Deliver Reproducible, Fit-For-Purpose Data.
  • Fit-For-Purpose Method Qualification Tailored To Support The Context Of Use (COU) For Cytokines In Exploratory Clinical Endpoints.
  • Fit-For-Purpose Method Qualification Tailored To Support The Context Of Use (COU) For Inflammation Cytokines In Exploratory Clinical Endpoints.

Comprehensive US-Based Central Lab Services For Cytokine Sample Analysis

  • Customized Clinical Collection Kits, Central Laboratory Services, And Long-Term Storage Options, Including Room Temperature, Refrigerated, And ULT Freezer Conditions.
  • High-Throughput Cytokine Sample Preparation For PBMC Preparation, Immunomagnetic Cell Separation, Tissue Lysis, Cell Lysis, Protein Isolation, Nucleic Acid Purification, And Sample Analysis. Multiplex Testing In Our Central Lab Provides Efficient Cytokine Analysis Across Multiple Analytes, Optimizing Therapeutic Insights.
  • Access To Extensive Testing Options In The Same Facility, Offering Valuable Insights Into Cytokine-Related Disease Mechanisms, Treatment Responses, And Therapeutic Monitoring. Our Cytokine Quantification Methods Ensure The Highest Accuracy For Clinical Analysis.

Safety And Efficacy Pharmacodynamic Cytokine Assay Services

  • Pharmacodynamic (PD) Cytokine Elisa Immunoassay Services To Confirm The Mechanism Of Action Of Drugs In Clinical Trials Through Precise Cytokine Level Measurements.
  • Application Of Analytical, Cellular, Or Functional Cytokine Assays For Inflammation Cytokines Biomarker Identification, Quantification, And Validation To Assess Therapeutic Effects And Response In Clinical Settings.

Cell-Based Cytokine Assays And Pharmacodynamic (PD) Assay Support

  • Proof-Of-Concept Driven, High-Value Cell Culture, And Cytokine Panel Assay Development To Assess Cytokine Activity, Potency, Mechanism Of Action (MOA), And Cytokine-Mediated Effects Such As Inflammation, Immune Responses, And Cytokine Release.
  • Biologically Relevant And Reliable Direct And Indirect Cell-Based Cytokine Panel Assays, Customized To Measure Cytokine Release, Cell Viability, Cell Proliferation, Apoptosis, Signaling Pathways, Reporter Gene Expression, And Receptor Binding In Response To Cytokine Activity.

Rapid And Reliable Gene Expression Analysis For Cytokine Profiling

  • qPCR Assays With Standard Curve And Reference Genes, Using Custom Or Pre-Designed Primers And Probes, To Measure Cytokine Gene Expression From RNA Isolates Derived From Tissues, Cells, Biofluids, FFPE Samples, And More.
  • Multiplex ddPCR Assays For Absolute Quantification Of Multiple Cytokine Target Genes In A Single Reaction, Enhancing Cytokine Profiling Service Without The Need For Standard Curves Or Endogenous Controls. This Enhances The Cytokine Quantification Process And Ensures Detailed, Actionable Results For Drug Development.
  • Our Cytokine Profiling Service Is Designed To Deliver Precise And Reliable Data Tailored To Meet Your Therapeutic Development Needs.

Cellular Protein-Based Cytokine Assay Services

  • Using The Latest Platforms And Bioanalytical Methods To Quantify The Levels And Activities Of Specific Proteins In Cells, Such As Cytokines, Receptors, Enzymes, Or Transcription Factors.
  • Customized, Fit-For-Purpose Cellular Protein-Based Cytokine Assays Tailored To Your Specific Needs, Including Multiplex Cytokine Assays And Flow Cytometry For Precise Inflammation Cytokines Analysis. Enhanced Cytokine Quantification Offers Greater Sensitivity And Resolution For Complex Cellular Analyses.

Our Cytokine Analysis Experts Have Deep and Diverse Experience with the Latest Bioanalytical Technologies!

Chemokine, Cytokine Assay

Development And Validation Of V-PLEX/S-PLEX MSD Assays For High-sensitivity Biomarker Analysis In Plasma, Urine, CSF, And Tissues

Cytokine Release Syndrome (CRS) Assay

Custom U-Plex MSD Multiplex ELISA Assay Development, GLP Validation, And Bioanalysis In Human Serum For CRS Studies

Cytokine Drug Discovery Assays

Compound Screening Using MSD, Luminex, AlphaLISA, And ELISA Platforms To Analyze Cytokine Levels In Cell Culture, Plasma, Serum, CSF, And Other Sample Types

Impurity Testing, Residual Testing

CRISPR/Cas9 MSD Biomarker Assay Development And Sample Analysis In Tissue/Cell Lysates

Cell-Based Cytokine Assay

MSD Assay Development And Sample Analysis For Cytokine Expression In Monocytes From Human PBMCs

TaqMan Gene Expression Assay

Customized Copy Number Multiplex Biomarker Assay On Digital dPCR In DNA Isolates From Human Cell Culture

Relative Gene Expression Assay

QRT-PCR For Cytokine Gene Expression Analysis With Multiple Housekeeping Genes In RNA From Non-human Primate (NHP) Tissues

LI-COR/Western Blot Analysis

Cytokine Assay Development, Optimization, And Sample Analysis Of Cytokines In Tissue, Pbmcs, Or Cell Lysates

Contact A Scientist For Your Cytokine Assay, Cytokine Analysis Services

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Comprehensive Suite of Cytokine Assay Services on Ligand Binding, PCR, and Chromatographic Platforms

Contact Us For Cytokine Assay Service Or Cytokine Analysis

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  • Your cytokine assays matter to us. Don’t let any bioanalytical lab overlook hidden challenges that could delay your therapeutic development
  • With our responsive and flexible cytokine assay services, we’ll expedite your drug development process
  • Our cytokine discovery assay expertise ensures rapid progress through regulatory submissions while staying within budget

20+

Years Of Immunoassay Lab Services With Industry-leading Turnaround Times

450+

Cytokine Assays Are Offered Using Commercial Kits Or Custom-designed Assays For Precise Cytokine Analysis

Expected Services Turnaround

Join NorthEast BioLab for cytokine assays in pharmacodynamic evaluation and drug discovery. Our team excels in immunoassays, PCR, cell-based assays, and chromatography. With expertise in multiplexing, sensitive assays, and matrix interference, we deliver cytokine assays in six to eight weeks. Your audited report, detailing validation and qualification, follows shortly after. We combine scientific expertise, regulatory experience, and operational excellence to optimize resources and reduce costs.

Requested Sponsor Input

We’re excited to collaborate on your cytokine assay. Our team values transparency and collaboration to ensure we understand your needs and expectations. To prepare a detailed proposal and timeline, please provide information about your assay requirements and study design, including cytokine analytes of interest, preferred reagents, current assay methodology, previous data, and study protocols (such as cohorts and sample sizes).

Reviews From Sponsors Of Our Cytokine Assay, Cytokine Analysis, Biomarker Assay, Biomarker Analysis Services

Head, Bioanalytical Development

“NorthEast BioLab goes the extra mile. We look forward to more meaningful collaborations.”

Sr. Dir., Bioanalytical Development & QC

NorthEast BioLab offers a science-based, hands-on approach to the latest bioanalytical platforms

VP, Bioanalytical Development

“NorthEast BioLab is the most responsive and thorough bioanalysis lab services CRO.”

VP, Development Operations

NorthEast BioLab’s scientists deliver high-quality data on time and within budget

VP, Biomarker Development 

NorthEast BioLab is a responsive, collaborative, and reliable partner

President & CSO, Biotech

We found their integrity as refreshing as readiness to provide creative scientific input and high-quality data

Contact Us For Cytokine Assay Service Or Cytokine Analysis

We Will Respond Within 1 Business Day

Expedite Your Ultra-Sensitive Cytokine Multiplex Analysis or Tailored Pharmacodynamic Assay with Our Cytokine Assay Experts

Extensive Cytokine Assay Development Expertise

  • We Review Your Cytokine Assay Methods, Data, And Regulatory Requirements To Ensure Optimal Results
  • Our Experts Specialize In Validating Assays With Commercial Supplies, Ensuring Accuracy And Reliability
  • With 30+ Years Of Experience And Strong Industry Ties, We Offer Regulatory Guidance Throughout The Development Process

Custom Cytokine Assay Services

  • We Provide Cytokine Assay Development With In-house Critical Reagent Tagging (e.g., Ruthenylation, Biotinylation) For Precision From The Start
  • Specializing In Singleplex And Multiplex Assays, We Focus On Fast Turnaround, Flexibility, And Continuous Feedback
  • Our Team Ensures Seamless Communication With Sponsors For Efficient Sample Preparation And Troubleshooting

Understanding Cytokines: Their Role in Immunity, Inflammation, and Disease

Cytokines are an integral part of our immune system that helps us respond to diseases. So, what are cytokines? Let us first define cytokines…

Our Streamlined Process For On-Time Delivery Of Entire Scope Of Work Within Sponsor Budget

Why Choose Us for Your Cytokine Testing Services?

20+ Years of Experience with Swift and High-Value Cytokine Assay and Pharmacodynamic Testing

Contact Us With Your Cytokine Assay

We Will Respond Within 1 Business Day
  • Tailored Multiplex Cytokine Assays For Crs Testing, Ensuring Accuracy
  • Pharmacodynamic Assays On Pbmcs, Dna/rna, And Tissue Lysates For Insights Into Cytokine Activity
  • Ultra-sensitive Assays For Preclinical/clinical Studies With Minimal Sample Volumes
  • Fit-for-purpose Cytokine Analysis For Therapeutic Monitoring And Compound Screening

Support Your Drug Innovation With Latest Equipment In Safe Hands Of Our Bioanalysis Experts

We Judiciously Invest In Our People, Solutions And Infrastructure, And Regularly Review Our Business Processes And Practices To Exceed Sponsor Expectations

Related FAQs

Answers to additional Cytokine Assays questions popular among our potential sponsors.

What Are Cytokines?

Cytokines are important proteins that help control immune responses, inflammation, and how cells communicate with each other. They are small signaling molecules made by different types of cells, especially immune cells, and they can affect how cells grow, develop, and survive. Tests for cytokines measure their levels, giving useful information about how the immune system works and how diseases progress.

What Do Cytokines Do?

Cytokines are vital for the immune system as they help cells talk to each other, managing immune responses, inflammation, and healing. They can either boost or reduce the activity of other cells, affect their growth, and guide the actions of cells involved in immune responses. Testing for cytokines is important to track these activities, which can be altered in diseases like autoimmune disorders, infections, and cancer.

What Is A Cytokine Storm?

A cytokine storm is a severe reaction where too many cytokines are produced, leading to intense inflammation that can harm tissues and cause organ failure. This can happen during serious infections, autoimmune diseases, or as a reaction to certain treatments. Testing for cytokine storms is essential for diagnosis and monitoring, using methods like cytokine panels to check the levels of cytokines linked to inflammation and immune system issues.

What Do Cytokines Provide To Cell Reproduction?

Cytokines affect cell reproduction by managing how cells divide and develop. They can encourage or slow down cell growth, aid in tissue repair, and help immune cells multiply during an immune response. Monitoring cytokines that impact cell growth, especially in immune reactions or inflammation, offers insights into how these processes are balanced.

What Is Cytokine Release Syndrome?

Cytokine release syndrome (CRS) happens when a large amount of cytokines is released into the blood, causing inflammation and possible harm to organs and tissues. It is often linked to certain cancer treatments like CAR T-cell therapy and severe infections. Checking cytokine levels with tests like cytokine panels and multiplex cytokine testing can help identify and manage CRS by pinpointing the specific cytokines involved in the inflammation.

What labs study cytokine storm?

Many research and clinical labs, including ours, focus on studying cytokine storms by measuring pro-inflammatory cytokine levels. These labs use advanced methods like multiplex cytokine assays to assess many cytokines at once, giving a detailed view of the immune response. Our cytokine testing services can help find important biomarkers related to cytokine storms, which can assist in early diagnosis and treatment.

What Is A Cytokine Panel?

A cytokine panel is a lab test that measures the levels of several cytokines at the same time, providing information about immune function, inflammation, and disease processes. It is often used in clinical settings to diagnose or track conditions like autoimmune diseases, infections, and inflammatory disorders. Panels may include cytokines such as Interleukin (IL), Interferons, and TNF-alpha, and can be tailored to the specific condition being examined. Our cytokine panel services use advanced techniques like cytokine ELISA and multiplex testing for precise and thorough results.

What Is A Multiplex Cytokine Assay?

A multiplex cytokine assay is a lab method that measures several cytokines at once from one sample. This efficient technique is great for examining complex immune responses and inflammation. It gives a wide view of the cytokines linked to diseases like cancer, autoimmune issues, and infections. Our multiplex cytokine assays offer clear insights into how cytokines interact and their impact on disease development.

What Is Cytokine Testing?

Cytokine testing involves lab techniques to check the levels of cytokines in samples like blood or tissue. These tests can evaluate how the immune system is working, the amount of inflammation, and various diseases. Common types of tests are cytokine panels, cytokine ELISA, and multiplex cytokine assays, all of which offer important information for research and medical diagnosis.

What Is Cytokine Analysis?

Cytokine analysis is the process of measuring and understanding the types and amounts of cytokines in a sample. This is important for studying immune responses, inflammation, and how diseases work. It helps find markers for different health issues, such as infections, autoimmune diseases, and cancer. Techniques like cytokine assays and multiplex testing are used to get detailed results.

What Are Pro-inflammatory Cytokines?

Pro-inflammatory cytokines are substances that encourage inflammation, usually due to infection, injury, or immune system activity. Examples include TNF-alpha, IL-6, and IL-1, which are key in triggering inflammation. Testing the levels of these cytokines can give valuable insights into chronic inflammation, autoimmune diseases, and other inflammatory issues.

What Is Cytokine Quantification?

Cytokine quantification measures how much cytokines are present in a biological sample. This can be achieved through methods like ELISA (Enzyme-Linked Immunosorbent Assay) or multiplex cytokine assays. Knowing the exact levels of cytokines is important for diagnosing and tracking inflammatory and immune-related diseases, allowing healthcare providers to customize treatments based on cytokine profiles.

What Is An Interferon Assay?

An interferon assay tests the amount of interferons, a type of cytokine that helps the immune system fight viral infections. Interferons are essential for activating immune cells and protecting the body from harmful invaders. These assays are valuable for diagnosing and monitoring viral infections and are also used in research to explore immune responses.

What Is An Interleukin Assay?

An Interleukin (IL) assay measures the levels of Interleukins, which are cytokines that regulate the immune system, signal cells, and manage inflammation. Different Interleukins, like IL-6, IL-10, and IL-12, play roles in various immune responses and can signal infections or autoimmune diseases. Interleukin assays are often included in a larger cytokine panel to evaluate immune system health.

What Is Interleukin Testing?

Interleukin testing checks the levels of specific Interleukins in biological samples to evaluate immune activity and inflammation. High or low levels of certain Interleukins, such as IL-1, IL-6, and IL-10, can suggest issues with the immune system, infections, or chronic inflammation. Our Interleukin testing services assist in diagnosing and monitoring diseases linked to abnormal Interleukin levels.

What Is A Cytokine Storm, And How Is It Related To Cytokine Release Syndrome (CRS)?

A cytokine storm refers to an overproduction of cytokines, leading to an exaggerated immune response. This can result in severe inflammation and damage to tissues. Cytokine Release Syndrome (CRS) is a severe form of cytokine storm often observed in immunotherapies or certain viral infections. Our lab offers specialized cytokine assays to monitor and study CRS for therapeutic development.

What Is A Multiplex Cytokine Assay And How Does It Differ From Traditional Assays?

A multiplex cytokine assay allows simultaneous detection and quantification of multiple cytokines in a single sample. Unlike traditional assays, which focus on a single cytokine, multiplex testing offers a broader analysis, saving time and resources while providing more comprehensive data on inflammation and immune responses.

How Accurate Is Cytokine Testing For Inflammation In Therapeutic Studies?

Cytokine testing, especially with multiplex assays, is highly accurate for assessing inflammatory responses in therapeutic studies. Our ultra-sensitive platforms like Meso Scale Discovery and Luminex are designed to provide precise quantification of pro-inflammatory cytokines, aiding in drug development and immune system profiling.

What Sample Types Are Suitable For Cytokine Analysis?

Our cytokine analysis services can be performed on various biological samples, including plasma, serum, urine, cerebrospinal fluid (CSF), PBMC isolates, tissue lysates, and cell culture supernatants. Each sample type is analyzed with high sensitivity using cutting-edge platforms to ensure reliable results.

What Is The Role Of Pro-inflammatory Cytokines In Immune Activation And Inflammation?

Pro-inflammatory cytokines play a central role in activating the immune system and promoting inflammation. They are key biomarkers in the assessment of diseases, infections, and therapeutic responses. Our multiplex cytokine testing focuses on these markers to track immune activation and inflammation levels.

What Platforms Do You Use For Multiplex Cytokine Testing?

We utilize advanced bioanalytical platforms for multiplex cytokine testing, including Meso Scale Discovery, Luminex, AlphaLISA, ELISA, qPCR/ddPCR, and LC-MS/MS. These platforms ensure ultra-sensitive detection and accurate quantification of cytokines across various sample types.

Can Cytokine Assays Be Customized For Specific Therapeutic Studies?

Yes, we offer customized multiplex cytokine assays tailored to specific therapeutic studies. Whether you are investigating cytokine release syndrome (CRS), inflammation responses, or pharmacodynamics, our assays are developed to meet the specific needs of your study, using a range of platforms and assay formats.

How Does GLP Cytokine Assay Validation Ensure Data Reliability In Clinical Studies?

GLP Cytokine Assay Validation ensures that cytokine assays are performed following Good Laboratory Practices (GLP) guidelines, using accredited equipment and high-quality reagents. This guarantees reproducibility, accuracy, and regulatory compliance, ensuring reliable data for clinical trials and therapeutic development.

What Is The Importance Of Cytokine Quantification In Research And Clinical Trials?

Cytokine quantification is crucial for assessing immune responses, evaluating therapeutic efficacy, and understanding disease mechanisms. By accurately measuring cytokine levels, researchers and clinicians can monitor disease progression, treatment effectiveness, and potential adverse effects in clinical trials.

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