Discovery and Research Biology

Target identification and validation

• Metabolic activity and functional behavior of biomolecules
• Protein-protein, protein-RNA, and protein-DNA interactions
• Small interfering RNA (siRNA) and gain-of-function studies

Assay development

• Biochemical assays with expression and purification of proteins
• Molecular Biology, including cloning, mutant generation, etc.
• Stable mammalian cell line generation

Lead optimization

• “Mechanism of action”, including pathway identification
• Compound profiling and pharmacology – early efficacy, safety, and toxicity