Test compound depletion measured by LC-MS/MS for intrinsic clearance and half-life
Cross-species hepatocyte incubations for intrinsic clearance, t½, metabolic soft spots
Cryopreserved human hepatocytes with mRNA fold-change and EC50 reporting across AhR, CAR, PXR
7-isoform IC50 panel and time-dependent IC50 shift in pooled human liver microsomes for DDI risk
Identification and characterization of drug metabolites using high-resolution mass spectrometry
Fraction unbound across species using rapid equilibrium dialysis
Apparent permeability and efflux ratios to flag P-gp substrates
DDI risk via MDR1, BCRP, OATP1B1/1B3, OAT1/3, OCT2, MATE1/2-K, BSEP substrate/inhibition
NorthEast BioLab goes the extra mile. We look forward to more meaningful collaborations
NorthEast BioLab offers a science-based, hands-on approach to the latest bioanalytical platforms
NorthEast BioLab is the most responsive and thorough bioanalysis lab services CRO
NorthEast BioLab’s scientists deliver high-quality data on time and within budget
NorthEast BioLab is a responsive, collaborative, and reliable partner
We trust NorthEast BioLab to design and execute streamlined, impactful bioanalytical projects