NorthEast BioLab Logo | Advanced Bioanalytical Services Lab Agile Bioanalytical Services CRO
  • Expertise
    • Menu IconAll Expertise
    • Menu IconMass Spectrometry (LC-MS)
      • Menu IconMass Spectrometry Services
      • Menu IconHPLC Testing Services
    • Menu IconMeso Scale Discovery Assay
    • Menu IconELISA Assay
      • Menu IconLuminex Multiplex Assay
    • Menu IconFlow Cytometry
    • Menu IconqPCR Analysis, ddPCR Assay
    • Menu IconWestern Blot, In Cell Western
  • Services
    • Menu IconAll Services
    • Menu IconPharmacokinetics (PK) Study
      • Menu IconToxicology (Tox) Study
      • Menu IconDose Formulation Analysis
      • Menu IconPK PD Analysis
      • Menu IconDrug Metabolism and Pharmacokinetics (DMPK)
      • Menu IconADME Studies
      • Menu IconBioequivalence and Bioavailability Studies
    • Menu IconADA Assay, Neutralizing Antibody Assay
    • Menu IconMultiplex Cytokine Assay
    • Menu IconBiomarker Assay
      • Menu IconBiomarker Assay List
    • Menu IconCell-Based Assay
      • Menu IconMechanism of Action (MOA) Studies
      • Menu IconCytotoxicity Assay
      • Menu IconBiochemical Assay
    • Menu IconBioanalytical Assay Validation
  • Solutions
    • Menu IconAll Solutions
    • Menu IconClinical CRO
      • Menu IconCentral Lab Services
      • Menu IconPBMC Services
    • Menu IconGLP Laboratory
      • Menu IconBioanalysis
      • Menu IconNon-GLP Testing
    • Menu IconPreclinical CRO
    • Menu IconMethod Development, Validation, And Transfer
      • Menu IconMethod Validation
      • Menu IconMethod Development
      • Menu IconMethod Transfer
    • Menu IconAnalytical Testing
      • Menu IconDiscovery Screening Services
      • Menu IconAnalytical Quantitation
      • Menu IconCosmetic Testing
  • About Us
    • Menu IconAbout Us
    • Menu IconOverview
    • Menu IconLeadership
    • Menu IconFacility and Equipment
    • Menu IconQuality and Compliance
    • Menu IconTherapeutic Areas
    • Menu IconWhy Us?
    • Menu IconValues
    • Menu IconProcess
    • Menu IconPartners
    • Menu IconCareers
      • Business Development Associate
      • Sr. Scientist – Cell Based Assay
      • GLP Quality Assurance Manager
      • Sr. Scientist, ELISA Immunoassay Bioanalysis
      • Sr. Scientist, LC-MS/MS Bioanalysis
      • Associate Scientist, Central Laboratory Services
      • Sr. Scientist - Pharmacokinetics (PK)
      • Content Manager, Scientific and Regulatory Writing
  • Resources
    • Menu IconLearning Center
    • Menu IconBlog
    • Menu IconCase Study
    • Menu IconVideo Brochures
    • Menu IconNews and Events
    • Menu IconTestimonials
    • Menu IconContact Us
  • Request Quote
NorthEast BioLab Logo | Advanced Bioanalytical Services Lab Agile Bioanalytical Services CRO Request Quote

Expertise

  • Menu IconAll Expertise
    • Menu IconMass Spectrometry (LC-MS)
      • Menu IconMass Spectrometry Services
      • Menu IconHPLC Testing Services
    • Menu IconMeso Scale Discovery Assay
      • Menu IconELISA Assay
        • Menu IconLuminex Multiplex Assay
      • Menu IconFlow Cytometry
        • Menu IconqPCR Analysis, ddPCR Assay
          • Menu IconWestern Blot, In Cell Western

            Services

            • Menu IconAll Services
              • Menu IconPharmacokinetics (PK) Study
                • Menu IconToxicology (Tox) Study
                • Menu IconDose Formulation Analysis
                • Menu IconPK PD Analysis
                • Menu IconDrug Metabolism and Pharmacokinetics (DMPK)
                • Menu IconADME Studies
                • Menu IconBioequivalence and Bioavailability Studies
              • Menu IconADA Assay, Neutralizing Antibody Assay
                • Menu IconMultiplex Cytokine Assay
                  • Menu IconBiomarker Assay
                    • Menu IconBiomarker Assay List
                  • Menu IconCell-Based Assay
                    • Menu IconMechanism of Action (MOA) Studies
                    • Menu IconCytotoxicity Assay
                    • Menu IconBiochemical Assay
                  • Menu IconBioanalytical Assay Validation

                    Solutions

                    • Menu IconAll Solutions
                      • Menu IconClinical CRO
                        • Menu IconCentral Lab Services
                        • Menu IconPBMC Services
                      • Menu IconGLP Laboratory
                        • Menu IconBioanalysis
                        • Menu IconNon-GLP Testing
                      • Menu IconPreclinical CRO
                        • Menu IconMethod Development, Validation, And Transfer
                          • Menu IconMethod Validation
                          • Menu IconMethod Development
                          • Menu IconMethod Transfer
                        • Menu IconAnalytical Testing
                          • Menu IconDiscovery Screening Services
                          • Menu IconAnalytical Quantitation
                          • Menu IconCosmetic Testing

                        About Us

                        • Menu IconAbout Us
                          • Menu IconOverview
                            • Menu IconLeadership
                              • Menu IconFacility and Equipment
                                • Menu IconQuality and Compliance
                                  • Menu IconTherapeutic Areas
                                    • Menu IconWhy Us?
                                      • Menu IconValues
                                        • Menu IconProcess
                                          • Menu IconPartners
                                            • Menu IconCareers
                                              • Menu IconBusiness Development Associate
                                              • Menu IconSr. Scientist – Cell Based Assay
                                              • Menu IconGLP Quality Assurance Manager
                                              • Menu IconSr. Scientist, ELISA Immunoassay Bioanalysis
                                              • Menu IconSr. Scientist, LC-MS/MS Bioanalysis
                                              • Menu IconAssociate Scientist, Central Laboratory Services
                                              • Menu IconSr. Scientist - Pharmacokinetics (PK)
                                              • Menu IconContent Manager, Scientific and Regulatory Writing

                                            Resources

                                            • Menu IconLearning Center
                                              • Menu IconBlog
                                                • Menu IconCase Study
                                                  • Menu IconVideo Brochures
                                                    • Menu IconNews and Events
                                                      • Menu IconTestimonials
                                                        • Menu IconContact Us

                                                          Request Quote

                                                            Contact Us

                                                            • Home
                                                            • Ultra-Low Temperature (ULT) Freezers in Drug R&D Laboratory

                                                            Ultra-Low Temperature (ULT) Freezers in Drug R&D Laboratory

                                                            By Vipin Agarwal, PhD
                                                            Share this article on:
                                                            Reading Time: 6 minutes

                                                            Ultra-Low Temperature (ULT) Freezers in Drug R&D Laboratory

                                                            It’s no secret that scientific research laboratories worldwide aren’t the most eco-friendly institutions. High energy utilization, single-use products, and continuous chemical consumption are among the many routine ways a laboratory can harm the environment. After all, biological sample management isn’t a piece of cake. However, we can proactively address improper laboratory practices to lessen their adverse environmental impact.

                                                            Ultra-low-temperature (ULT) freezers are indispensable for clinical sample storage, but they are also one of the biggest culprits for energy consumption in research laboratories. On average, they consume 16–25 kWh per day per freezer. At NorthEast BioLab, we currently have 10+ ULT freezers in use. If handled improperly, these freezers could meter up a large energy bill and an even larger carbon footprint. We have taken multiple steps to lessen our freezers’ energy consumption and negative environmental impact.

                                                            Incorporating sustainable practices into our sample study protocols has been a priority. We have developed guidelines for sample storage, emphasizing efficient use of freezer space and optimizing inventory management to reduce the number of freezers required. We have implemented temperature monitoring systems to ensure our freezers operate at the optimal temperature range, minimizing energy waste.

                                                            For instance, implementing a clinical sample management system that optimizes freezer space utilization reduces the need for additional freezers and energy consumption. This approach ensures efficient clinical trial sample management, adhering to sample clinical trial protocols and sample study protocols while minimizing environmental impact. Regularly defrosting and maintaining ULT freezers ensures optimal performance, minimizing energy wastage. We’ve also transitioned to energy-efficient ULT freezer models and explored alternative cooling technologies to reduce our environmental footprint further.

                                                            By adopting sustainable practices in biological sample management, such as optimizing freezer usage and investing in energy-efficient equipment, laboratories can significantly reduce their environmental impact while maintaining the integrity of their biological sample collection and clinical sample storage for research and clinical purposes. Implementing protocol samples for clinical research that include guidelines for efficient freezer utilization and maintenance can further enhance the sustainability of sample management practices in clinical research.

                                                            Set up for success

                                                            To optimize biological sample management and ensure the integrity of clinical samples, NorthEast BioLab implements several key practices:

                                                            Raise The Set Temperature From -80oC to -70oC

                                                            This practice will not affect sample integrity, but it will lower the freezer’s energy consumption by 1-2 kWh per day. Lowering the stress on the compressor will also raise the freezer’s life span, aligning with the sample study protocol requirements for protocol samples for clinical research.

                                                            Do not set up freezers in small rooms/hallways

                                                            ULT freezers in small spaces work the compressors harder to maintain the set temperature. This can increase the room temperature by 10-15oC and stress the lab’s HVAC system further. Ensuring proper spacing around freezers is crucial for maintaining temperature stability and prolonging equipment life, essential for adhering to sample clinical trial protocol requirements.

                                                            Ensure that all freezers have at least eight inches of surrounding space

                                                            ULT freezers produce plenty of heat. If that heat has nowhere to go, it will cycle back into the freezer motor, causing the motor to work harder and use more energy. Adequate ventilation is vital for maintaining consistent temperatures, ensuring the quality and integrity of clinical sample storage, and aligning with the sample study protocol in clinical research.

                                                            Install a two-way ventilation system

                                                            At NorthEast BioLab, we have an adjustable exhaust system behind all our freezers. The hot air generated is expelled outdoors during summer and circulated throughout the lab to assist in heating during winter. This ensures optimal temperature control year-round, which is crucial for clinical sample storage, especially in clinical trial sample management, where maintaining consistent conditions is paramount.
                                                            By implementing these measures, NorthEast BioLab maintains optimal conditions for biological sample collection, clinical sample management, and overall biological sample management, safeguarding sample integrity while maximizing energy efficiency and equipment longevity.

                                                            Stay on the course

                                                            Staying on course with proper freezer maintenance is crucial for efficient biological sample management, ensuring the integrity of clinical sample management and the upkeep of biological sample collections.

                                                            Do not let ice/frost buildup occur in the freezer

                                                            Ice/frost lining of the seal gasket on the door happens over time. This allows cold air to seep out and warm air to seep in, which can compromise clinical trial sample management. Thus, it is important to check for frost and ice buildup regularly, at least once a month. Otherwise, it can make biological sample management very difficult.

                                                            Regularly clean air filters and motor coils

                                                            Dust and grime accumulate over the air filter and motor coils over time, making the freezer motor work harder than needed. This can impact clinical sample storage efficiency and the overall sample clinical trial protocol and protocol samples for clinical research. Regular cleaning of these components can reduce freezer energy consumption by up to 25%. While it’s important to check this every few months, cleaning is generally only required once per year.

                                                            Replace Old ULT Freezers

                                                            When freezers reach the end of their lifespan, they can begin to use 2-4 times as much energy as when they were brand new, affecting clinical sample storage. The average lifespan of a ULT freezer is 7-10 years when operating at -80oC and 10-12 years at -70oC. Considering the importance of clinical trial sample management, replacing old ULT freezers to reduce energy consumption and maintaining the integrity of the biological sample collection as per the clinical sample storage standards is advisable. Even though new ULT freezers are expensive (generally around $12,000-15,000), the savings from a reduction in energy usage can easily be over $1,000 annually. So, consider replacing your old ULT freezers to reduce energy consumption to keep clinical trial sample management efficient and the biological sample collection intact.

                                                            Monitor Temperature 24×7

                                                            Temperature monitoring not only ensures sample integrity but also provides actionable data regarding the freezer’s energy usage and efficiency. At NorthEast BioLab, we check each freezer’s temperature chart at least once per week.

                                                            Telltale signs of an inefficient freezer include:

                                                            • Average temperature observed below the set temperature
                                                            • Significant rising and falling temperatures when the freezer doors have remained closed
                                                            • Gradual increase / decline in average temperature over any period

                                                            All these signs can point to an aging compressor that will soon fail and is likely using more energy than needed, or a leak in the freezer allows warm air in.

                                                            Even though the energy consumed by ULT freezers will likely always be quite significant, we still can’t avoid using them, as they are crucial for any drug R&D laboratory and pivotal for clinical trial sample management and biological sample management. However, it’s noteworthy that their energy consumption can be greatly decreased by following a few simple steps during setup, monitoring, and maintenance. While many eco-friendly clinical sample management practices implemented at laboratories come with significant costs, lessening ULT freezers’ energy consumption can help the environment and your wallet. By following proper setup, monitoring, and maintenance of sample clinical trial protocols or protocol samples for clinical research, laboratories can decrease energy usage while maintaining the integrity of biological sample collections.

                                                            Registered And Inspected By Various Regulatory Agencies

                                                            Speak To Our Scientist About Ultra-Low Temperature (ULT) Freezer Capabilities For Clinical Lab Services

                                                            SPEAK TO OUR SCIENTISTS

                                                            Similar Blog Posts

                                                            • Diving Deep: Real-Time Quantitative PCR vs. Digital PCR Analysis (dPCR) for Gene Expression & Copy Number Analysis – An In-depth Comparison

                                                            • MAb ELISA Protocol, MAb ELISA Development, MAb Bioanalytical Testing

                                                            • Neutralizing Antibody Assay, NAb Assay Service, NAb Analysis

                                                            • Multiplex Cytokine Analysis Using Meso Scale Discovery

                                                            • What are Matrix Effect in Liquid Chromatography Mass Spectrometry?

                                                            • What are the Best Practices of LC-MS/MS Internal Standards?

                                                            • Positive and Negative Mode in Mass Spectroscopy: LC-MS/MS Method | NorthEast BioLab

                                                            Explore Our Solutions

                                                            • Clinical CRO

                                                            • GLP Laboratory

                                                            • Preclinical CRO

                                                            • Method Development Validation and Transfer

                                                            • Analytical Testing

                                                            Contact A Scientist With Your Bioanalytical Study Details

                                                            We Will Respond Within 1 Business Day

                                                            Expertise

                                                            Expertise

                                                            • Mass Spectrometry (LC-MS)
                                                            • Meso Scale Discovery Assay
                                                            • ELISA Assay
                                                            • Flow Cytometry
                                                            • qPCR Analysis, ddPCR Assay
                                                            • Western Blot, In Cell Western

                                                            Services

                                                            Services

                                                            • Pharmacokinetics (PK) Study
                                                            • ADA Assay, Neutralizing Antibody Assay
                                                            • Multiplex Cytokine Assay
                                                            • Biomarker Assay
                                                            • Cell-Based Assay
                                                            • Bioanalytical Assay Validation

                                                            Solutions

                                                            Solutions

                                                            • Clinical CRO
                                                            • GLP Laboratory
                                                            • Preclinical CRO
                                                            • Method Development, Validation, And Transfer
                                                            • Analytical Testing

                                                            About Us

                                                            About Us

                                                            • Overview
                                                            • Leadership
                                                            • Facility and Equipment
                                                            • Quality and Compliance
                                                            • Therapeutic Areas
                                                            • Why Us?
                                                            • Values
                                                            • Process
                                                            • Partners
                                                            • Careers

                                                            Resources

                                                            Resources

                                                            • Learning Center
                                                            • Blog
                                                            • Case Study
                                                            • Video Brochures
                                                            • News and Events
                                                            • Testimonials
                                                            • Contact Us
                                                            NorthEast BioLab Logo Agile Bioanalytical Services CRO
                                                            sales@nebiolab.comFollow Up On Email
                                                            (203) 361 3780Follow Up On Phone

                                                            35 Worth Ave, Hamden, CT 06518

                                                            • Good Laboratory Practice for Nonclinical Laboratory Studies | NorthEast BioLab
                                                            • Food and Drug Administration (FDA | NorthEast BioLab
                                                            • clia
                                                            • United States Drug Enforcement Administration | NorthEast BioLab
                                                            • Department of Consumer Protection | NorthEast BioLab
                                                            • Privacy Policy
                                                            • Terms of Use
                                                            • Sitemap
                                                            All rights reserved.